上海乾思生物

生命科学产品一站式供应商

服务热线:021-34556080

产品中心

PRODUCTS CENTER

当前位置:首页产品中心优势品牌QuidelA114Quidel Complement Activator(补体活化剂)

Quidel Complement Activator(补体活化剂)
产品简介:

产品货号:A114
产品名称:Quidel Complement Activator(补体活化剂)
产品规格:0.2 mL
产品品牌:Quidel
热聚合伽马球蛋白作为一种有效的经典补体途径激活剂,其功能类似于天然存在的免疫复合物。当被强效激活剂(例如 Quidel 的补体激活剂)激活时,给定补体源中的几乎所有 C4 都可以转化为裂解产物。

产品型号:A114

更新时间:2021-08-31

厂商性质:代理商

访 问 量 :1337

服务热线

021-34556080

立即咨询
产品介绍

产品货号:A114
产品名称:Quidel Complement Activator(补体活化剂)

产品规格:0.2 mL
产品品牌:Quidel

热聚合伽马球蛋白作为一种有效的经典补体途径激活剂,其功能类似于天然存在的免疫复合物。当被强效激活剂(例如 Quidel 的补体激活剂)激活时,给定补体源中的几乎所有 C4 都可以转化为裂解产物。

Quidel Complement Activator(补体活化剂)产品描述:

   The classical pathway of complement can be triggered by antibody bound to a foreign particle (immune complex, cell or other material). Particles of this type interact directly with C1q. C1q can then activate the C1r(2)C1s(2) sub-units of the C1 complex. The activated C1s cleaves C4 to C4b near the amino terminus of the gamma chain releasing C4a in the process. Activation of the Classical Pathway is under stringent control in vivo. C4b is rapidly degraded to iC4b and then to C4c and C4d. Because of the short life of the C4b molecule, much of the C4d isfree and circulatesin serum. Assuch C4d is an excellent marker for classical complement activation in vivo or in vitro and istherefore the basis of the MicroVueTM C4d EIA Kit (Item A008).

    The activity of the resulting complement activator is assessed using the MicroVue C4d EIA kit. 10 µl of Activator is incubated with 1.0 mL of a reference serum (Normal Human Serum Complement, Cat. A113) at 37˚C for 90 minutes. At fixed time points, samples of the reference serum are taken. Ice cold 20 mM EDTA is added to each sample to block further complement activation; the samples are stored on ice until assay. Upon completion of the activation phase, the resulting samples are assayed in the MicroVue C4d kit. The results (µg C4d/mL) are graphed vs. time for each sample. Full activation is shown by a rapid increase in C4d concentration followed by a plateau. Quidel’s complement activator will fully activate the classical complement pathway of the reference sera within 30 minutes at 37˚C.

在线留言

ONLINE MESSAGE

留言框

  • 产品:

  • 您的单位:

  • 您的姓名:

  • 联系电话:

  • 常用邮箱:

  • 省份:

  • 详细地址:

  • 补充说明:

  • 验证码:

    请输入计算结果(填写阿拉伯数字),如:三加四=7
  • 服务热线 021-34556080
  • 电子邮箱

    info@biobaiye.com

扫码加微信

Copyright © 2025 上海乾思生物科技有限公司版权所有    备案号:沪ICP备2023041625号-1

技术支持:化工仪器网    sitemap.xml